Grand Theft Auto 4 singleplayer takes 56 hours to finish
VGB reports that Jeronimo Barrera, a senior developer at Rockstar, says it takes testers playing 4 hours a day "a good 2 weeks to get through the whole single-player game." That means if they are playing a full week that's about 56 hours total.
(Grand Theft Auto IV, PS3, Xbox 360)