Game Vortex writes: "Destroy All Humans: Big Willy Unleashed is the first game in the series not developed by Pandemic and the change shows. While it isn't a horrible game by any means, it also doesn't come together as well as previous titles.
Overall, the game looks like it was developed with the PSP in mind rather than the Wii. Environments are blocky and textures are washed out and really flat. The same goes for everything that populates the environment. While you would expect humans and other disposable entities to feature fewer details, even the game's two biggest stars, Crypto and Big Willy look bad. On the plus side, the lighting and other special effects (like explosions) look good, as does the animation.
Sound is one of the presentation's saving graces. Like past games, the soundtrack is a mix of 70's music and a few original tracks that go with the original's "50's alien invasion" theme. The voicework is as good as ever, and even though the jokes aren't quiet as funny as in the previous two games, the delivery still works."