Eurogamer writes: "You can guess what to expect from the humour in Destroy All Humans: Big Willy Unleashed. They said willy! You know! As in a man's penis! As in my friend Billy had a ten foot willy and he showed it to the girl next door, she thought it was a snake so she hit it with a rake and now he's doing time because she's four. Except Big Willy Unleashed isn't as mature or witty as that.
Here's what else you can expect from the game: an abominable control system, tedious missions, hideous visuals and laughable multiplayer options. Even fans of the original Destroy All Humans games won't find anything to enjoy in this, the series' first Wii instalment in the series. And, if there's any justice, the last."