Extreme Gamer writes: "The first Destroy All Humans! Came out blasting in 2005 when Pandemic Studios introduced gamers to the little "grey" alien called Crypto for the Playstation 2 and Xbox. A year later Pandemic returned with a sequel that wasn't half the effort we seen in the original. Destroy All Humans! is a franchise rich with potential, so a new Destroy All Humans! game had me giddy with anticipation, but this anxiety has a little reserve. Since Electronic Arts has snagged up Pandemic Studios we have a new developer Locomotive Games. Locomotive has worked with THQ in the past releasing some so-so efforts like MX Superfly and WWE Crush Hour, the Twisted Metal version of wrestling... weird, I know. It's now time for them to move on to bigger and better ideas and this brings us to Destroy All Humans! Big Willy Unleashed.
Crypto return in Big Willy Unleashed brings brings him in the 1970s when fast food restaurants are spreading across the country like wild fire. Big Willy's is the McDonalds of Destroy All Humans being the biggest franchise of them all. Little do the human population know that Big Willy's is actually a front for Crypto and Pox to harvest more humans. In a sick twist it is explained that these terrible two are actually feeding us left over parts from our own bodies in the menu at Big Willy's. Funny, or disgusting, it looks like the humour in Destroy All Humans! is still intact. The plot continues as the Kolonel Klucken, Big Willy's competition is trying to expose the secret behind the restaurant which gives the premise for Big Willy Unleashed. Unleashed, you have to take on the Kolonel and his minions, Crypto style, which is always fun."