DSOGaming writes: "Resident Evil 6 is not friendly with either SLI or Crossfire systems, as owners of a multi-GPU system will notice negative scaling on their GPUs. This negative scaling occurs in random places and can be easily noticed in the second Chapter (Cathedral) of Leon’s campaign. As we can see below, the game was running with 51fps and – after a while – with 119fps. Performance was inconsistent with SLI enabled, and the Cathedral level was almost unplayable due to the random framerate drops. When we disabled SLI, we were gaming with constant 119fps on that very same level."