Our intrepid heroes have fought long and hard to make their way to this point. They’ve devastated every mook and lieutenant that’s been thrown at them; they’ve exploited every single flaw they could find in the antagonist’s machinations, and they have, for all intents and purposes, emerged victorious.
Well, except for one tiny, troublesome detail: the villain wanted them to succeed.
Here’s a tribute to a few of the most manipulative, most intelligent, and most effective villains from throughout video game history.
Alone, they're easy however; when fought together, they make up for the other's weakness which I believe gives them the #1 spot.
As for the list here, it's a good one. Well, aside from The Illusive Man. He... couldn't be described as cunning at all, and only barely passed muster as a villain.
I'd replace him with Marcello from Dragon Quest VIII, though he was a bit less of a villain and a bit more of an anti-hero.
i can't really say what he did, because, well, spoilers.
but damn,that bastard's sneaky.