In the middle of a piece by Karsten Lund, a longtime IO employee currently at Square Enix Montreal, he casually mentions the following:
"IO Interactive have been doing a very good job of putting the player front and center and have given us some of the most memorable moments in gaming; emergent stories of how players completed missions shared at the water cooler, this to me is the core DNA of a Hitman game. I know how hard that is to create; I was at Io for the last 11 years. Our challenge is obviously to retain that DNA, while establishing ownership in our team and of our game."
In other words: The next Hitman game won't be coming from IO Interactive.