Resident Evil 6 starts with a bang. That bang being right in the zombie-president’s head. It's an opening that pretty much sets the trend for the whole game: Shooting zombies in the head. Which is probably the best thing you could hope for in a zombie game really.
The game revolves around you playing one of three pairs of protagonists, each with their own story, as they combat the bio-terrorist (basically, zombies) attacks that are appearing across the globe.