Naomi Brown writes "There is a huge focus on story in this game. Because the movie reboot has changed the Spiderman back-story and focuses more on a biological explanation for Spidey's change, the game follows along with that mythos. In the game, there are hunters sent out by Oscorp in order to help reign in all of the cross species in Manhattan. In addition to the baddies like Rhino, Lizard and Iguana, Spiderman counts as a cross species. He has to deal with the hunters coming out to track him down over the course of the game, engaging him in intensive combat throughout the city."